Comparision study of total parenteral nutrition and parenteral nutrition combining enteral nutrition in severe acute pancreatitis

Objective To explore the changes of indicators for total parenteral nutrition (TPN) and parenteral nutrition (PN) combining enteral nutrition (EN) support in patients with severe acute pancreatitis (SAP), and to analyze the treatment effects of two groups. Methods 29 patients with SAP were randomly divided into two groups: TPN group (n=14) and PN+EN group (n=15). Nonoperative treatment were applied to the two groups. The changes of indicators and therapeutic outcome of two groups were recorded after nutrition support 14 days. Results After 14 days nutritional support, serum albumin (ALB), total serum protein (TSP), blood calcium, glutamic-pyruvic transaminase (ALT), glutamic-oxaloacetic transaminase (AST) in each group increased significantly (P 0.05). The APACHE II scores, average hospital days, average hospital charges, incidence of infection and mortality rate in the PN+EN group were significantly lower than that in the TPN group (P<0.05). ConclusionsPN combining EN support was superior to TPN in the treatment of patients with SAP. Key words: Severe acute pancreatitis; Total parenteral nutrition; Parenteral nutrition; Enteral nutrition