Observation of prone position ventilation effectiveness in treatment of newborn with acute lung injury and acute respiratory distress syndrome

Objective To explore the effect of prone position in combination with noninvasive mechanical ventilation on the treatment of the newborns with acute lung injury /acute respiratory distress syndrome (ALI/ARDS). Methods Selected 90 cases of newborns with ALI/ARDS who were treated in the neaonate intensive care unit from October 2014 to October 2015. According to the random number table method, all the selected cases were divided into the observation group and the control group, corresponding random numbers as even into the observation group and odd numbers into the control group, 45 cases in each group. The control group was implemented the supine ventilation, while the observation group was implemented the prone position ventilation. The implementation was given every four hours at a time, one hour each treatment. Then, the changes of hemodynamic indexes and blood gas analysis index of two groups of patients were compared at the beginning of the ventilation (0 h), 2 h and 24 h, respectively. Results The ventilation way of both groups played a little role in improving the hemodynamic effects. There was no significant difference in the comparison of mean arterial pressure, central venous pressure of two groups of newborns at the different times (P > 0.05). However, heart rate in the observation group was (103.1±3.7) beats/min had dramatically improved after ventilated 24 h when compared with (111.8±5.6) beats/min in the control group (t=8.70, P 0.05). Conclusions The prone position ventilation can better improve oxygenation of newborns with ALI/ARDS, and it can promote oxygenation and correct hypoxia by improving the newborn's the ratio of ventilation/blood flow. Therefore, it's worth scaling up its clinical application. Key words: Prone position; Acute lung injury; Acute respiratory distress syndrome; Noninvasive mechanical ventilation