Exudative erythema multiforme caused by piperacillin sodium and tazobactam sodium in a child

An 11-year-old boy with pneumonia received an IV infusion of azithromycin 0.375 g once daily and piperacillin sodium and tazobactam sodium 1.25 g every 8 hours after 3 days of azithromycin treatment. On day 8 of azithronycin treatment, the boy's condition was improved markedly and azithromycin was stopped. On day 12, the boy developed fever and on day 14 his highest temperature reached 39.0 ℃. On day 12, piperacillin sodium and tazobactam sodium was withdrawn. On day 16, a large area of erythema multiforme appeared in the boy's face, neck, and trunk. The rash increased gradually, fused into lamella, and emerged into blisters and rupture. Symptomatic treatments were given. Ten days later, the boy's rashes was improved and was discharged. Key words: Piperacillin; Erythema multiforme; Drug eruptions