Toxic epidermal necrolysis induced by piperacillin sodium and tazobactam sodium

A 15-year-old boy with intracranial infection received an IV infusion of piperacillin sodium and tazobactam sodium 4.5 g dissolved in 0.9% sodium chloride injection 100 ml, once per 6 hours. About six hours after IV infusion, the boy developed dark red rash which had pinpoint or rice grain size all over the body. Flaccid blisters were appeared on surface of part of the rash. His skin temperature gone up, combined with pruritus and tenderness pain obviously. His body temperature was between 37.4-37.7℃. The result of examination of Nikolsky′s sign was positive. He was diagnosed as toxic epidermal necrolysis due to piperacillin sodium and tazobactam sodium. Piperacillin sodium and tazobactam sodium was stopped. The boy received the treatments of anti-infection, antianaphylaxis, and enteral nutrition, etc. Sixteen days later, the rash on his face, body, arms and legs faded away. The result of follow up by telephone one month later showed that there was no scar on the boy′s skin. Key words: Piperacillin sodium and tazobactam sodium; Toxic epidermal necrolysis