Advance in the immune mechanism of sepsis in children

Sepsis is one of the common critical clinical syndromes caused by infection.Currently, in worldwide, although a certain progress has been made in medical therapies and techniques, the morbidity and mortality of infectious diseases associated with pediatric sepsis have been increasing over years, leaving sepsis still being one of the most important reasons resulting in death.The pathogenesis of sepsis is complicated, which has not been fully elucidated, including infection, inflammation, immune injury, coagulation abnormalities, tissue damage and so forth.A large number of experiments show that immune mechanism plays an important role in the occurrence and development of sepsis.This article will review the literature on the immune mechanism of sepsis in children. Key words: Sepsis; Pathogenesis; Child; Immune