Comparison of the effect of citalopram and fluoxetine in the treatment of depression

Objective To compare the effect and side effects of citalopram and fluoxetine in the treatment of depression.Methods 46 cases meet the diagnostic criteria of CCMD-3 in patients with depression were randomly divided into citalopram group and fluoxetine group,treatment for 6 weeks,with Hamilton Depression Rating Scale (HAMD) and Emergent Symptom Scale(TESS) assessed the efficacy and adverse reactions.Results The efficiercy in citalopram group was 75.4％,74.8％ for the fluoxetine group,the difference between the two groups was not significant ( P＞0.05).Affter 2weeks treatment HAMD score between the two groups was significantly different (P ＜ 0.05),TESS score in Citalopram group was lower than the fluoxetine group,the differences were significant ( P ＜ 0.05 ).Conclusion Citalopram and fluoxetine have good antidepressant effects.Citalopram has the advanteges of early onset,cess adverse reactions. Key words: Depression;  Citalopram;  Fluoxetine