The Clinical Studies on the Expression of Survivin Protein in Nasopharyngeal Carcinoma

Objective To explore the relationship between the expression of apoptotic inhibitor gene Survivin protein and the clinical stage,radiosensitivity,prognosis in patients with nasopharyngeal carcinoma.Methods IImmunohistochemical staining of Survivin was performed by the two-step technique of standard MaxvisionTM for the paraffin section of 128 patients with nasopharyngeal low differentiation squamous-cell carcinoma.Results The expression of Survivin protein was observed in 90 nasopharyngeal carcinoma.The expression of Survivin and its strong expression rate were associated with the clinical stage by Statistical analysis(P0.01),but the difference of Survivin expression between Ⅲ and Ⅳ had no statistical significance;The positive percent of survivin expression in nasopharyngeal carcinoma with lymph node metastasis,recurrence or distant metastasis were higher than that without those metastasis(P0.05).③ the expression of Survivin protein was associated with the clinical radiosensitivity by statistical analysis(P0.05).Conclusion Survivin is highly expressed in nasopharyngeal carcinoma.The overexpression of Survivin protein is strongly associated with clinical stage,prognosis,radiosensitivity of nasopharyngeal carcinoma.Survivin thus may be a new predictor for the diagnosis,radiosensitivity and prognosis in patients with nasopharyngeal carcinoma.