2012•Chinese Journal of AsthmaRequires access
Anti-fibrosis effect of histone deacetylase inhibitors
Qing Ye, Yanqin Li
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Abstract
Histone acetylation/deacetylation modification is the key mechanism for regulating gene transcription,and this modification is regulated by histone acetyltransferase and histone deacetylases.Recent studies have shown that histone deacetylases are related with the diseases mainly characterized by chronic fibrosis.It is shown that histone deacetylase inhibitors can inhibit fibrotic reaction in both vivo and vitro experiments.In this paper,the effects of histone deacetylase inhibitors on anti-fibrosis are reviewed.
Key words:
Histone deacetylase inhibitors; Antifibrotic