2004•Chinese New Drugs JournalRequires access
Advances in pharmacological study of histone deacetylase inhibitors
Liu Na
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Abstract
Acetylation of histone involves in the regulation of gene expression. The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases. Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins , and specifically modulate some gene expression. The pharmacological actions of histone deacetylase inhibitors and their potential clinical uses were reviewed.