2013•肿瘤研究与临床Requires access
Research progress in endostatin and tumor
Ranran Zhang, Li Li, Rongyao Xia
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Abstract
Angiogenesis plays an important role in tumor growth and metastasis,anti-angiogenic therapy is becoming the center point in tumor therapy,endostatin is a recently discovered endogenous inhibitor of angiogenesis.Endostatin can specifically target endothelial cells,inhibiting proliferation and migration and inducting apoptosis.This review describes the mechanism of endostatin in inhibiting angiogenesis,induction of apoptosis in tumor cells and clinical trials.
Key words:
Neoplasms; Endostatin; Neovascularization, pathologic; Apoptosis; Therapy