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EXPRESSION AND PROGOSTIC VALUE OF E-CADHERIN AND PROLIFERATING CELL NUCLEAR ANTIGEN IN SAMPLES FROMGASTRIC CARCINOMAS AND LYMPH-NODE METASTASES

姜汉国, 唐慰萍, 曹军, 吴冬梅

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Abstract

目的研究胃腺癌及配对淋巴结转移灶中上皮性钙粘素(E-cd)和增殖细胞核抗原(PCNA)的表达及意义.方法应用免疫组织化学法检测20例正常胃黏膜、20例异型增生、109例胃癌及淋巴结转移灶中E-cd和PCNA表达.结果 E-cd和PCNA在异型增生、胃癌及淋巴结转移灶中阳性表达率分别为85%(17/20)、40.37%(44/109)、23.85%(26/109)和25%(5/20)、74.31%(81/109)及77.98%(85/109)三者之间有显著差异(P<0.01).E-cd和PCNA表达与胃腺癌Lauren分型和预后显著相关.结论 E-cd和PCNA可反映胃腺癌的生物学特性,是预测患者预后有价值的指标.

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目的研究胃腺癌及配对淋巴结转移灶中上皮性钙粘素(E-cd)和增殖细胞核抗原(PCNA)的表达及意义.方法应用免疫组织化学法检测20例正常胃黏膜、20例异型增生、109例胃癌及淋巴结转移灶中E-cd和PCNA表达.结果 E-cd和PCNA在异型增生、胃癌及淋巴结转移灶中阳性表达率分别为85%(17/20)、40.37%(44/109)、23.85%(26/109)和25%(5/20)、74.31%(81/109)及77.98%(85/109)三者之间有显著差异(P<0.01).E-cd和PCNA表达与胃腺癌Lauren分型和预后显著相关.结论 E-cd和PCNA可反映胃腺癌的生物学特性,是预测患者预后有价值的指标.

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Available abstract

目的研究胃腺癌及配对淋巴结转移灶中上皮性钙粘素(E-cd)和增殖细胞核抗原(PCNA)的表达及意义.方法应用免疫组织化学法检测20例正常胃黏膜、20例异型增生、109例胃癌及淋巴结转移灶中E-cd和PCNA表达.结果 E-cd和PCNA在异型增生、胃癌及淋巴结转移灶中阳性表达率分别为85%(17/20)、40.37%(44/109)、23.85%(26/109)和25%(5/20)、74.31%(81/109)及77.98%(85/109)三者之间有显著差异(P<0.01).E-cd和PCNA表达与胃腺癌Lauren分型和预后显著相关.结论 E-cd和PCNA可反映胃腺癌的生物学特性,是预测患者预后有价值的指标.

Key concepts: Lymph node, Pathology, Antigen, Value (mathematics), Proliferating cell nuclear antigen, Cadherin, Medicine, Immunohistochemistry

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