董来荣, 王 桂华
Abstract
目的:探讨CD44v6和细胞核增生抗原(PCNA)在结直肠癌组织中的表达情况与临床病理关系.方法:采用ABC和SP免疫组化方法检测84例结直肠癌组织中的CD44v6和PCNA的表述情况,用统计学X2检验分析CD44v6和PCNA的表达意义.结果:CD44v6和PCNA在大肠癌组织中的表达具有一致性,与癌肿的浸润深度及淋巴转移、Dukes′分期呈正相关,与年龄、性别及组织学类型无关.结论:结直肠癌组织中CD44v6和PCNA呈高表达是预后差的生物学指标,而高增生状态的癌细胞对化疗敏感,故对CD44v6和PCNA呈高表达患者予严格的术后化疗,可望提高疗效.
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目的:探讨CD44v6和细胞核增生抗原(PCNA)在结直肠癌组织中的表达情况与临床病理关系.方法:采用ABC和SP免疫组化方法检测84例结直肠癌组织中的CD44v6和PCNA的表述情况,用统计学X2检验分析CD44v6和PCNA的表达意义.结果:CD44v6和PCNA在大肠癌组织中的表达具有一致性,与癌肿的浸润深度及淋巴转移、Dukes′分期呈正相关,与年龄、性别及组织学类型无关.结论:结直肠癌组织中CD44v6和PCNA呈高表达是预后差的生物学指标,而高增生状态的癌细胞对化疗敏感,故对CD44v6和PCNA呈高表达患者予严格的术后化疗,可望提高疗效.
Key concepts: Colorectal cancer, Cancer, Medicine, Oncology, Proliferating cell nuclear antigen, Mouse model of colorectal and intestinal cancer, Cancer research, Internal medicine