2007Chinese Journal of AsthmaRequires access

Clinical study of noninvasive positive pressure ventilation in severe respiratory failure of chronic obstructive pulmonary disease

安福成, 谢永强

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Abstract

目的 评价无创正压通气(NIPPV)救治慢性阻塞性肺疾病(COPD)合并严重Ⅱ型呼吸衰竭的治疗效果.方法 前瞻性研究25例伴严重Ⅱ型呼吸衰竭(PaCO2>80 mm Hg)的COPD急性发作期患者,在常规治疗基础上给予NIPPV治疗,并监测血气、临床征象等情况.结果 NIPPV 3 h迅速改善了患者的心率(HR)、呼吸频率(RR)和血气(PH、PaCO2)(P<0.01),通气24 h可获进一步改善(P<0.01).插管率12%,病死率8%.结论 NIPPV是治疗COPD合并严重Ⅱ型呼吸衰竭的有效手段。

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目的 评价无创正压通气(NIPPV)救治慢性阻塞性肺疾病(COPD)合并严重Ⅱ型呼吸衰竭的治疗效果.方法 前瞻性研究25例伴严重Ⅱ型呼吸衰竭(PaCO2>80 mm Hg)的COPD急性发作期患者,在常规治疗基础上给予NIPPV治疗,并监测血气、临床征象等情况.结果 NIPPV 3 h迅速改善了患者的心率(HR)、呼吸频率(RR)和血气(PH、PaCO2)(P<0.01),通气24 h可获进一步改善(P<0.01).插管率12%,病死率8%.结论 NIPPV是治疗COPD合并严重Ⅱ型呼吸衰竭的有效手段。

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Available abstract

目的 评价无创正压通气(NIPPV)救治慢性阻塞性肺疾病(COPD)合并严重Ⅱ型呼吸衰竭的治疗效果.方法 前瞻性研究25例伴严重Ⅱ型呼吸衰竭(PaCO2>80 mm Hg)的COPD急性发作期患者,在常规治疗基础上给予NIPPV治疗,并监测血气、临床征象等情况.结果 NIPPV 3 h迅速改善了患者的心率(HR)、呼吸频率(RR)和血气(PH、PaCO2)(P<0.01),通气24 h可获进一步改善(P<0.01).插管率12%,病死率8%.结论 NIPPV是治疗COPD合并严重Ⅱ型呼吸衰竭的有效手段。

Key concepts: Medicine, Pulmonary disease, Positive pressure ventilation, Respiratory failure, Acute respiratory failure, Noninvasive ventilation, Ventilation (architecture), Intensive care medicine

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