Study on the correlation between the serum levels of IFN-γ, IL-18, IL-10 and recurrent spontaneous abortion

Objective To explore the correlation between the serum levels of interferon (IFN)-γ, interleukin (IL)-18, IL-10 and recurrent spontaneous abortion (RSA). Methods Enzyme-linked immunosorbent assay was used to detect the serum levels of IFN-γ, IL-18 and IL-10. There were 40 patients with RSA (RSA group) and 40 normal early pregnant women (control group) enrolled in this study. After 2 months, those serum cytokines in two groups of non-pregnant state were detected again. Results Compared to control group, the serum levels of IFN-γ and IL-18 of RSA group were significantly higher (P<0.01), the serum level of IL-10 was significantly lower (P<0.01). Two months after termination of pregnancy, there was no significant difference in the serum levels of IFN-γ and IL-10 between the two groups. The serum level of IL-18 maintained a high level in the RSA group after termination of pregnancy. Conclusions In patients with RSA, the serum levels of IFN-γ and IL-18 were elevated, the serum level of IL-10 was decreased. The serum levels of IFN-γ, IL-18 and IL-10 were closely related with RSA. Key words: Abortion, habitual/ME; Interferon type Ⅱ/ME; Interleukin-10/ME; Interleukin-18/ME