Study of the Correlation of Gastric Metaplasia,Helicobacter Pylori Infection, and Shimofuri Lesion

Objective:To learn the relationship of shimofuri lesion with Helicobacter pylori infection and duodenal ulcer(DU).Methods:Density of Helicobacter pylori(Hp)in gatric antral mucosa,degree of inflammation and gastric metaplasia(GM)in duodenal mucosa were measured in subjects endoscopically assessed as duodenal ulcer,shimofuri lesion,duodenitis and normal duodenal bulbs.All patients with shimofuri lesion were randomly divided into ranitidine suppressing acid group(ranitidine group)and ant i Hp therapy group(anti Hp group),then two groups were secondly observed with gas troscope.Results:Thc inflammation degree between various mucosa lesion cach other were different( P 0 05)and shimofuri lesion was the most serious duodenitis.Both the Hp density and the GM degree were no difference between DU and shimofuri lesion( P 0 05).26 subjects of 42 shimofuri were repeated endoscopy at 4 weeks.The endoscopic findings were 5 shimofuri lesion(lcom-plicated duodenal ulcer)in the ranitidine group(14) Vs 0 in the anit Hp group(12)( P 0 0425).Conclusions:serious active duodenitis resulted by Hp may be the pathological base of DU and shimof uri lesion may be a precursor of DU.