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The effects of Panax quinquefolium saponins on proliferation of cultured human fetal RPE cells

明月, 庞惠民, 庞利民

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Abstract

目的研究西洋参茎叶总皂甙(PQS)对人视网膜色素上皮细胞(RPE)增生的抑制作用.方法通过活细胞计数法与MTT比色法分别检测不同质量浓度(10 μg/ml～500 μg/ml)PQS和PQS (200 μg/ml)在不同作用时间(6～120 h)对RPE增生及代谢的影响.结果PQS组细胞增殖受抑制,细胞生存率下降,400 μg/ml抑制作用最强;其抑制效应在6 h出现,72 h达高峰.结论PQS可能通过阻滞钙通道、干扰RPE代谢对RPE增殖具有剂量和时间依赖方式的抑制作用.

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What this paper is about

目的研究西洋参茎叶总皂甙(PQS)对人视网膜色素上皮细胞(RPE)增生的抑制作用.方法通过活细胞计数法与MTT比色法分别检测不同质量浓度(10 μg/ml～500 μg/ml)PQS和PQS (200 μg/ml)在不同作用时间(6～120 h)对RPE增生及代谢的影响.结果PQS组细胞增殖受抑制,细胞生存率下降,400 μg/ml抑制作用最强;其抑制效应在6 h出现,72 h达高峰.结论PQS可能通过阻滞钙通道、干扰RPE代谢对RPE增殖具有剂量和时间依赖方式的抑制作用.

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Available abstract

目的研究西洋参茎叶总皂甙(PQS)对人视网膜色素上皮细胞(RPE)增生的抑制作用.方法通过活细胞计数法与MTT比色法分别检测不同质量浓度(10 μg/ml～500 μg/ml)PQS和PQS (200 μg/ml)在不同作用时间(6～120 h)对RPE增生及代谢的影响.结果PQS组细胞增殖受抑制,细胞生存率下降,400 μg/ml抑制作用最强;其抑制效应在6 h出现,72 h达高峰.结论PQS可能通过阻滞钙通道、干扰RPE代谢对RPE增殖具有剂量和时间依赖方式的抑制作用.

Key concepts: Fetus, Araliaceae, Saponin, Chemistry, Traditional medicine, Biology, Pregnancy, Medicine

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