Influence of different dose dexmedetomidine on postoperative acute agitation and time to eyes opening in pediatric sevoflurane anesthesia

Objective To investigate the effective dose of dexmedetomidine on reducing agitation after sevoflurane anesthesia in patients undergoing repair of indirect inguinal hernia .Methods 105 patients （ ASAⅠ-Ⅱ） were randomly assigned into three groups ,35 cases in each group .In the observation group 1 and observation group 2, the patients received intravenous injection of dexmedetomidine 0.15μg/kg and 0.30μg/kg respectively.In the control group,the patients received intravenous injection of 0.9% normal saline solution 2mL before surgery.All patients were induced by 3%sevoflurane and maitained by 1.2%sevoflurane and hiatus sacralis block .During the operation, the BP,HR,SpO2,RR were recorded.At the end of anesthesia,the time to eyes opening （TEO） and agitation of emer-gence were recorded.Results The TEO of the control group,observation group 1,observation group 2 was （8.45 ± 4.02）min,（9.23 ±5.03）min,（10.81 ±4.06）min,respectively,and there were no significant differences among the three groups（all P〉0.05）.The incidence rate of agitation of the observation group 1 was 20.00%,which was signifi-cantly lower than that in the control group （42.86%） （χ^2 =31.42,P〈0.05 ）,and that of the observation group 2（8.57%） was significantly lower than the control group and observation group 1（χ^2 =24.37,7.53,all P〈0.05）. Conclusion The dose of dexmedetomidine 0.3μg/kg administered after induction of anesthesia can reduce the post-sevoflurane agitation in children and with no adverse effects . Key words: Dexmedetomidine; Sevoflurane; Anesthesia