2009•白血病·淋巴瘤Requires access

Advance in the pathogenesis and treatment of acute promyelocytic leukemia

Qinfen Xie, Jie Jin, Jian Huang

Abstract

Pathogenesis of acute promyelocytic leukemia is one of the best understood disease among human hematological malignancies. Becasue of retinoic acid (RA) and arsenic trioxide which directly target the oncogenic promyelocytic leukemia-retinoic receptor A (PML-RARα) fusion protein, this disease became the first model for oncogene-targeted therapies.And other new therapy methods also gain great concern. The complexity of recent views of acute promyelocytic leukemia pathogenesis, as well as latest progress in clinical treatment were summarized and discussed in this review. Key words: Leukemia; PML-RARα; Tretinoin; Therapy

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Available abstract

Key concepts: Acute promyelocytic leukemia, Arsenic trioxide, Promyelocytic leukemia protein, Pathogenesis, Leukemia, Medicine, Cancer research, Retinoic acid