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2006•Journal of the National Comprehensive Cancer NetworkOpen access

Strategies for the Treatment of Acute Promyelocytic Leukemia

Olga Frankfurt, Martin S. Tallman

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Abstract

The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

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What this paper is about

The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

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Available abstract

The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

Key concepts: Acute promyelocytic leukemia, Medicine, Leukemia, Promyelocytic leukemia protein, Intensive care medicine, Immunology, Genetics, Retinoic acid

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