Relationship between the expression of proto oncogene c-Ski in non-small cell lung cancer and the early metastasis of tumor

Objective To explore the relationship between the expression of proto oncogene c-Ski in non-small cell lung cancer and the early metastasis of tumor. Methods From January 2015 to July 2016, 97 patients with non-small cell lung cancer in the People's Hospital of Pingxiang were selected.The protein expression of c-Ski was examined with immunohistochemical SP and real-time PCR, the results were observed and compared. Results The positive rates of c-Ski protein and mRNA level in non-small cell lung cancer tissues and adjacent normal tissues were 18.6% and 79.4%, respectively, the difference was statistically significant(χ2=71.80, P<0.01). The positive rate of c-Ski protein expressed in non-small cell lung cancer patients was related with age, clinical stage and pathologic classification, the differences were statistically significant(χ2=8.40, 4.72, 15.71, all P<0.05). Conclusion c-Ski may play an important role in the invasion and metastasis of non-small cell lung cancer, which can be used as a potential therapeutic target for non-small cell lung cancer in the future. Key words: Carcinoma, non-small-cell lung; Proto-oncogenes; Immunohistochemistry; Polymerase chain reaction