2012•International Journal of Dermatology and VenereologyRequires access
Skin-derived antimicrobial peptides
Yuan-yuan Qu, Xiongming Pu
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Abstract
Antimicrobial peptides refer to all of the peptides with antimicrobial activity expressed in various types of organisms.Skin-derived antimicrobial peptides play an important role in the protection of skin against infection by frequently contacting microbes in the environment.They mainly consist of defensins and cathelicidin LL-37.Since skin-derived antimicrobial peptides possess a series of advantages which are lacked by common antibiotics,their biological activity and correlation with skin barrier have become a hot spot in present studies.Further researches into skin-derived antimicrobial peptides will provide new hopes for thedefense against diseases,delay of aging,disclosure of pathogenesis of and development of treatment for somedermatoses.
Key words:
Epidermis; Defensins; Cathelicidins; Skin barrier