Distribution and antibiotic resistance surveillance of infection pathogens isolated from hematology ward from 2010 to 2014

Objective To investigate the distribution and antibiotic resistance of infection pathogens isolated from hematology ward. Methods Bacterial susceptibility test was carried out by K-B method. Data were analyzed by WHONET 5.4 software. Results A total of 667 pathogens were isolated and collected, including gram-negative bacilli (55.7%), gram-positive cocci (33.3%) and fungi (11.0%). The dominant source of pathogens was blood (40.9%), sputum (26.0%) and urine (14.0%). The top 3 pathogens were Escherichia coli (15.1%), Coagulase negative Staphylococcus (15.1%) and Klebsiella pneumoniae (10.1%). About 46.8 % of Klebsiella pneumoniae and 62.0% of Escherichia coli produced extended spectrum β-lactamases. The sensitive rates of Klebsiella pneumoniae and Escherichia coli to imipenem and meropenem were both more than 95%. The resistance rates of Pseudomonas aeruginosa to levofloxacin, imipenem, meropenem, Cefoperazone/sulbactam, piperacillin/tazobactam were lower than 20%. More than 85% strains of Stenotrophymonas maltophilia were susceptible to levofloxacin, cotrimoxazole and minocycline. The prevalence of methicillinresis tant coagulase-inegative staphylococci and methicillin resistant staphylococcus aurreus were 34.6% and 76.6% in Coagulase negative staphylococcus and Staphylococcus aureus, and strain resistant to teicoplanin was isolated. The susceptibility of Enterococcus spp. to teicoplanin and vancomycin were 84.1% and 70.3%, respectively. Gram-positive cocci resistant strains to teicoplanin and vancomycin were isolated. Conclusions Gram-negative bacilli keep the most prevalence pathogens in the hematology ward and high susceptibility to empirical antimicrobial agents. But the antibiotic resistance to glycopeptide antibiotics was getting worsen for the major gram-positive cocci. Key words: Hematologic diseases; Infection pathogens; Antibiotic resistance