2012•Central Plains Medical JournalRequires access

Changes and significance of lymphocyte subsets in children with severe aplastic anemia

Yange Li, Hongmei Zhang, Huixia Li, Yanna Mao, Wei Liu, Junshan Liu

Abstract

Objective To study the changing characteristics of T-lymphocyte subsets in children with severe aplastic anemia(SAA).Methods Flow cytometry was used to detect the peripheral blood T-lymphocyte subsets of 28 cases of SAA(treatment group)and 30 cases of normal children(control group),and the results were compared.Results The numbers of CD3 + cells increased(P＜0.05)andCD8 + cells increased significantly(P＜0.01),CD4 + cells reduced(P＜0.05),and CD4 +/CD8 + cells ratio decreased obviously(P＜0.01)in treatment group.Conclusions Patients with AA have great changes in peripheral blood T-lymphocyte subsets.Detection of the changes is important for evaluation of the cellular immune function condition,making auxiliary diagnosis and guiding therapy in children with SAA. Key words: Children with severe aplastic anemia; T-lymphocyte subsets

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Key concepts: Aplastic anemia, CD8, Lymphocyte subsets, Flow cytometry, Medicine, Immunology, Immune system, CD3