2010•Guoji zhongliuxue zazhiRequires access

Molecular mechanisms involved in EMT regulated invasion and metastasis of pancreatic cancer

Guanghui Zhu, Zhengjun Qiu

Abstract

Loss of epithelial characteristics and acquisition of a mesenchymal phenotype are the main features of epithelial-mesenchymal transition (EMT). EMT plays an important role in tumor invasion and metastasis through increasing cell migration, invasion and anti-apoptotic capacity. Several mechanisms involved in EMT regulate invasion and metastasis of pancreatic cancer,including cadherin switch, growth factors, transcription factors, microRNA and signaling pathways. Key words: Epithelial cells; Stromal cells; Pancreatic neoplasms; Neoplasm metastasis

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Key concepts: Metastasis, Epithelial–mesenchymal transition, Pancreatic cancer, Cancer research, Stromal cell, microRNA, Biology, Phenotype