2013•Guoji zhongliuxue zazhiRequires access

Chemokine receptor CXCR7 and tumor

Nana Wang, Ying Bai

Abstract

CXCR7 is a new receptor of chemokine CXCL12 after CXCR4.The present study shows that CXCL12/CXCR7 biological axis has important influence to the development of a variety of tumors,similar to CXCL12/CXCR4 biological axis.CXCR7 is present in many kinds of tumor tissues and tumor cells widely,and plays an important role in tumor cells growth,proliferation,adhesion and migration.Restraining CXCR7 expression or blocking the CXCR7 signaling pathways may offer new strategies for the treatment of tumors. Key words: Neoplasms; Chemokine CXCL12; CXCR7

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Key concepts: Chemokine, Chemokine receptor, CXCR4, Cancer research, Receptor, Tumor cells, Cell biology, Biology