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2010•Zhongguo linchuang shiyong yixueRequires access

Clinical significance of changes of serum IL-6 TNF-o and NPY levels in patients with Hypoxic Ischemic Encephalopathy(HIE)

Hong Zhou, Yan Hu, Guo-yu Wei

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Abstract

Objective To explore the clinical significance of changes of serum IL-6 TNF-α and NPY levels in patients with HIE.Methods Serum IL-6 TNF-α and NPY levels(with RIA) were detected in 32 patients with HIE,as well as 35 controls.Results Serum IL-6 TNF-α and NPY levels were significantly higher in the patients HIE than those in controls(P＜0.01).Serum IL-6 levels were positively correlated to serum TNF-α and NPY levels(r = 0.6045,0.5714,P＜0.01).Conclusion Serum IL-6 TNF-α and NPY levels are closely related to the diseases process of HIE and determination of which are of great clinical importance. Key words: Hypoxic Ischemic Encephalopathy(HIE); Interleukin-6(IL-6); Tumor necrosis factor-2(TNF-α); Neuropeptide Y(NPY)

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Objective To explore the clinical significance of changes of serum IL-6 TNF-α and NPY levels in patients with HIE.Methods Serum IL-6 TNF-α and NPY levels(with RIA) were detected in 32 patients with HIE,as well as 35 controls.Results Serum IL-6 TNF-α and NPY levels were significantly higher in the patients HIE than those in controls(P＜0.01).Serum IL-6 levels were positively correlated to serum TNF-α and NPY levels(r = 0.6045,0.5714,P＜0.01).Conclusion Serum IL-6 TNF-α and NPY levels are closely related to the diseases process of HIE and determination of which are of great clinical importance. Key words: Hypoxic Ischemic Encephalopathy(HIE); Interleukin-6(IL-6); Tumor necrosis factor-2(TNF-α); Neuropeptide Y(NPY)

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Available abstract

Objective To explore the clinical significance of changes of serum IL-6 TNF-α and NPY levels in patients with HIE.Methods Serum IL-6 TNF-α and NPY levels(with RIA) were detected in 32 patients with HIE,as well as 35 controls.Results Serum IL-6 TNF-α and NPY levels were significantly higher in the patients HIE than those in controls(P＜0.01).Serum IL-6 levels were positively correlated to serum TNF-α and NPY levels(r = 0.6045,0.5714,P＜0.01).Conclusion Serum IL-6 TNF-α and NPY levels are closely related to the diseases process of HIE and determination of which are of great clinical importance. Key words: Hypoxic Ischemic Encephalopathy(HIE); Interleukin-6(IL-6); Tumor necrosis factor-2(TNF-α); Neuropeptide Y(NPY)

Key concepts: Neuropeptide Y receptor, Clinical significance, Medicine, Internal medicine, Endocrinology, Tumor necrosis factor alpha, Hypoxic Ischemic Encephalopathy, Encephalopathy

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Clinical significance of changes of serum IL-6 TNF-o and NPY levels in patients with Hypoxic Ischemic Encephalopathy(HIE) — Research Paper | ScholarLens