Intravitreal triamcinolone acetonide for the treatment of macular edema associated with central retinal vein occlusion

Objective To evaluate the efficacy and complication of Intravitreal triamcinolone acetonide(IVTA)in the treatment of macular edema associated with central retinal vein occlusion(CRVO).Methods Thirty eyes of 30 patients with severe macular edema due to CRVO underwent IVTA with 4mg/0.1 ml.Best-corrected visual acuity,intraocular pressure(IOP),inflammatory extent,manifestation of lens and fundus were observed before treatment and one day,three days,one week,one month,three months after treatment.The retinal thickness was examined by optic coherent tomography(OCT).Results Of all 30 eyes 22 eyes(73%)had improved visual acuity,3 eyes(10%)remained the same.2 eyes(7%)had secondaryglaucoma,2 eyes(7%)had supervented cataract and 1 eye(3%)had retinal detachment.The LogMAR visual acuity was 0.78+0.50 before treatment,while 1 week,1 monm and 3 months after IVTA,the average visual acuity was 0.62±0.48.0.45±0.37 and 0.3 1±0.28 respectively.The average retinal thickness at macular area was 589±1 32um before treatment.while 1 week,1 month and 3 months afterIVTA.the average retinal thickness was(341±122)μ m;(201±61)μm;(162+41)μ m respectively,which had statistical significance compared with thatbefore treatment(P＜0.01).5 eyes(17%)of all 30 eyes had high intraocularpressure (IOP),temporarily,and IOP was controlled after treated with topical eye drop.2 eyes(7%)had secondary glaucoma,with the treatment of trabeculectomy.2 eyes(7%)had supervented cataract.1 eye(3%)had retinal detachment,with the treatment of laser photocoagulation.Conclusions IVTA is effective for macular edema secondary to CRVO in a short time,while the complication can not be ignored. Key words: Retinal vein occlusion/therapy; Triamcinolone acetonide/therapeutic use; Macular edema/drug therapy; Complication