Effects of high frequency oscillatory ventilation in the newborn meconium aspiration syndrome

Objective To evaluate the effects of high frequency oscillatory ventilation (HFOV)in the newborn meconium aspiration syndrome. Methods Twenty -one newborns with meconium aspiration syndrome performed the HFOV after failure of conventional mechanical ventilation(CMV). The O2 saturation,the ratio of a/A PaO2, arterial blood gas and oxygenation index were monitored in the course of HFOV. Results The FiO2 reduced significantly after 2 hours HFOV, the ratio of a/A PaO2 increased significantly(P <0. 05) ,and the change was high significantly after 6 hours HFOV(P <0. 01). There was no the adverse effect of pulmonary barotraumas and bronchopulmonary dysplasia. Conclusions HFOV is an effective method for neonatal infants with severe MAS after failure of CMV. Key words: High frequency oscillatory ventilation ;  Newborn ;  Meconium aspiration syndrome ;