Influence of High Frequency Oscillation Ventilation to Pathological Change During Meconium Induced Lung Injury

Objective To investigate the therapeutic foundation of HFOV on rabbit models with ALI induced by meconium through the observation on pathological changes in lungs and to highlight the feasibility of clinical application of HFOV.(Methods)Twenty-eight rabbits were randomly divided into groups as controls(n=6),conventional ventilated(CV)(n=7) and HFOV(n=9) after ALI induced by meconium was established and the normal group((n=6)) too.Six hours after the intervention the pathological changes of lung tissue was examined under microscope.The variances of pathologic change were analyzed by Kruskal-Wallis(K-W). Results The pathological changes such as infiltration of the inflammatory cells,edema injury of micro airways was significantly severe in CV group than those in HFOV group.The formation of hyaline membrane was not found in all groups. Conclusion HFOV is effective than the CV for decreasing lung injury when treating ALI caused by meconium indicating that HFOV is more feasible for clinical application and thus should be selected for use as the main clinical techniques when treating neonates with MAS.