Effect of subclinic hypothyroidism on pregnant outcome

Objective To observe the effect of subclinical hypothyroidism and thyroid hormone therapy on pregnancy outcome. Methods A total of 123 pregnancy women with subclinic hypothyroidism were enrolled in this study. All the pregnancy women were divided into two groups: levothyroxine intervention group(n=46) received thyroid hormone therapy, and observation group(n=77) did not receive treatment.100 cases of normal pregnancy women were selected as a normal population control group. During pregnancy 8-12 weeks, 16-20 weeks, and 28-32 weeks, thy thyroid tests include FT4, TSH, TPOAb. Results In the total 2 780 cases, 123 cases were subclinic hypothyroidism with a rate of 4.42%. In control group, observation group, and intervention group, the incidence of abnomal glucose metabolism was 7.0%, 20.77% and 10.86%; the incidence of hypertension was 2.0%, 15.58% and 2.17%; the incidence of anemia was 3.0%, 18.18% and 4.34%; the incidence of spontaneous abortion was 3.0%, 25.77% and 8.69%; the incidence of newly born mortality was 0, 7.79% and 4.34%; the incidence of premature was 2.0%, 15.58% and 6.52%. Statical analysis showed that these indicators in observation group was significantly higher than that in the control and intervention group(P 0.05). There was no significant difference in the incidence of the weight of newborns among the three groups(P>0.05). Conclusions Pregnant women with subclinical hypothyroidism have high incidence of adverse pregnancy outcomes, and those clinical application can be intervented by thyroid hormone treatment. Key words: Pregnant; Subclinical hypothyroidism; Intervention treatment