Aplication of Thyroxine Tablets in Treatment of Subclinical Hypothyroidism in Pregnancy

Objective To explore the incidence of subclinical hypothyroidism during pregnancy and the clinical outcome after thyroid hormone replacement therapy. Methods We retrospectively analyzed the data of the patients with early pregnancy, 237 cases were diagnosed subclinical hypothyroidism. According to whether the patients received thyroid hormone replacement therapy or not, the patients were divided into treatment group(168cases) and control group(69 cases),and then we compared the clinical outcome. Results There were 5 455 cases enrolled in the study, and 237 cases were diagnosed with subclinical hypothyroidism, 37 cases with clinical hypothyroidism and 19 cases with hypothyroxinemia. In treatment group, the incidence of adverse pregnancy outcomes such as threatened abortion and so on were significantly lower than that in control group, the differences were statistically significant(P 0.01). Conclusions Thyroid hormone replacement therapy can reduce the incidence of adverse pregnancy outcomes. This study suggests it is necessary to porform the thyroid function screening for the patients in early pregnancy.