TACE or three-dimensional radiotherapy for patients of malignant biliary obstruction after stent placement

Objective To evaluate transcatheter arterial chemoembalization (TACE)and/or threedimentional radiotherapy for the prevention of stent restenosis in patients of malignant biliary obstruction.Methods In this series,45 cases of malignant biliary obstruction after stent placement were randomly divided into three groups,15 cases in each group.Group A patients received TACE management,patients in group B were treated with three-dimensional conformal radiotherapy,patients in group C received supportive therapy.On 1,2,3,4 months after stent placement,intra-stent biopsy was performed,obstruction was managed by stent replacement.Results Time of stent patence was 102,94 and 51 days respectively in group A,B,and C.3 months survival rate was 93％,87％ and 60％ respectively; 6 months survival rate was 60％,47％ and 20％ respectively; 9 months survival rate was 20％,13％ and 0 respectively.Conclusions For malignant biliary obstruction after biliary tract stenting,TACE and or 3D radiation therapy can effectively prevent stent restenosis caused by tumor growth. Key words: Bile ducts, intrahepatic;  Antineoplastic combined chemotherapy protocols;  Obstruction, malignant ;  Stent restenosis ;  Radiology, interventional