Clinical efficacy of carbamazepine, topiramate combined with levetiracetam in the treatment of traumatic refractory epilepsy

Objective To study the effect of carbamazepine, topiramate combined with levetiracetam in the treatment of traumatic refractory epilepsy. Methods One hundred patients with traumatic intractable epilepsy from January 2014 to January 2017 were studied prospectively. They were divided into 2 groups by random digits table method with 50 cases each group. The control group received topiramate combined with carbamazepine, and the observation group was given carbamazepine, topiramate combined with levetiracetam treatment. All cases were treated for 6 months. The clinical efficacy of the 2 groups, patients with epilepsy, cognitive function score and the incidence of adverse reaction were compared. Results The total effective rate in observation group was 96% (48/50), in control group was 82% (41/50), and there was statistical difference (P 0.05. Conclusions The clinical effect of carbamazepine, topiramate combined with levetiracetam on traumatic intractable epilepsy can effectively reduce the onset and duration of epilepsy, and improve the cognitive function of patients. The risk of adverse reactions did not increase. This treatment is reliable and safe. Key words: Epilepsy, post-traumatic; Carbamazepine; Topiramate; Levetiracetam