2010•International journal of pediatricsRequires access
Melanocortin 4 receptor and children obesity
Jian-fang Chu
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Abstract
Mutations in the melanocortin 4 receptor (MC4R) represent the most common known cause of monogenic human obesity.MC4R is a family of the five melanocortin receptors.It is an exon lying on chromosome 18.Studies have proved that there is a closed relationship between MC4R and weight regulation.MC4R mutation can result in severer adolescent obesity.
Key words:
Obesity; Melanocortin 4 receptor ; Gene mutation