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Melanocortin-4 Receptor Gene Mutations and Obesity

Stuart C. Sherman

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Abstract

Obesity is caused by the interaction of multiple genetic and environmental factors. Several genes involved with appetite have been identified: α-melanocyte-stimulating hormone is an anorexigenic peptide and a potent agonist of the melanocortin-4 receptor (MC4R). In 2 studies, researchers evaluated the link between MC4R gene mutations and obesity. In the first study, 5.8% of 500 subjects with severe early-onset obesity (before age 10) had mutations …

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What this paper is about

Obesity is caused by the interaction of multiple genetic and environmental factors. Several genes involved with appetite have been identified: α-melanocyte-stimulating hormone is an anorexigenic peptide and a potent agonist of the melanocortin-4 receptor (MC4R). In 2 studies, researchers evaluated the link between MC4R gene mutations and obesity. In the first study, 5.8% of 500 subjects with severe early-onset obesity (before age 10) had mutations …

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Available abstract

Obesity is caused by the interaction of multiple genetic and environmental factors. Several genes involved with appetite have been identified: α-melanocyte-stimulating hormone is an anorexigenic peptide and a potent agonist of the melanocortin-4 receptor (MC4R). In 2 studies, researchers evaluated the link between MC4R gene mutations and obesity. In the first study, 5.8% of 500 subjects with severe early-onset obesity (before age 10) had mutations …

Key concepts: Melanocortin 4 receptor, Obesity, Melanocortin, Gene, Endocrinology, Agonist, Appetite, Melanocortin 3 receptor

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