Detecion of human papillomavirus genotype and its distribution characteristics of the polulation

Objective To analysis of the prevalence and genotype distribution of human papilloma-virus (HPV) in Heyuan city.Methods 6745 cases of epithelial cell specimens were subjected HPV subtype screening by HybriMax technology.Results Among the 6745 women,1701 women were HPV positive.The overall prevalence of HPV was 25.20％ (1701/6745).Among the HPV-positive women,74.40％ (1265/1701) were infected with a single HPV type,and 25.63％ (436/1701) were infected with more than one.Infections with double and multiple subtype of HR-HPV was common.Infected with more than six types just were below the age of 24.There were no women infected with more than five type of HPV over the age of 50.We observed a Ushaped age-specific prevalence curve with a first peak over the age of 60 and a second peak below the age of 24 for overall HPV infection,low-risk HPV infection and high-risk HPV infection.The most common subtype was HPV52 (25.69％),followed by HPV16(17.34％)and HPV58(15.52％) in the 15 HR-HPV subtypes,HPV81 (8.23 ％) was the most common subtype in 6 LR-HPV subtypes,followed by HPV6 (6.94％).There is a difference in HPV subtype infection among age groups.Conclusion The high rate of HPV infection is observed in Heyuan city.Multiple HPV infections were identified in 25.63％ of the positive specimens,Two peaks of HPV prevalence were observed in women who were over the age of 60 and below the age of 24 for overall HPV infection,low-risk HPV and high-risk HPV types and the most common subtype was HPV52.There is a difference in HPV subtype infection among age groups. Key words: Human papilloma-virus;  PCR-HybriMax ;  Genotype ;  Cervix cancer