Infection and genotype distribution of human papilloma virus(HPV) in female in Wenzhou

Objective:To investigate the infection and genotype distribution of human papilloma virus in female in Wenzhou for development and application of HPV vaccine.Methods: The cervical samples of 4314 women were detected with flow-through hybridization and gene chip on HPV subtype was also analyzed.Results: The HPV positive rate was 41.68%(1798/4314).Screened women were mainly between 31 to 50 years old in 10 age groups,accounting for 72.02%.The higher HPV positive rates were occupied by 21 to 25 years old group(56.86%) and ≥60 years old group(64.39%).The common HPV infection in 10 age groups was mainly single infection,secondly double infection.In single HPV infection,HPV16,HPV52 and HPV58 were the most frequent high risk subtypes,HPV18 and HPV33 were the secondly frequent high risk subtypes;HPV6 and HPV11 were the most frequent low risk subtypes;HPV53 and HPV cp8304(81) were the most frequent common subtypes.Conclusion: The most common HPV infection was single infection in Wenzhou.The predominate high risk subtype was HPV16,HPV52 and HPV58,the predominate low risk subtype was HPV6 and HPV11,the predominate common subtype was HPV53 and HPV cp8304(81).