2014•Guoji zhongliuxue zazhiRequires access

ERCC1 gene polymorphism in gastric cancer.

Yuan Tian, Zezhi Shan, Jiayuan Peng, Yu Wang

Abstract

As a crucial part of the DNA damage repair process,the expression of excision repair cross-complementing group 1 （ERCC1 ）is closely related to the genesis and development of gastric cancer.Studies find that ERCC1 gene polymorphism can alter the expression of the gene itself,which affects the sensitivity and efficacy of platinum-based chemotherapy.Therefore,the detection of ERCC1 polymorphism may guide the indi-vidualized chemotherapy of the patients with gastric cancer. Key words: Stomach neoplasms; Polymorphism, single nucleotide; ERCC1

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Key concepts: ERCC1, Nucleotide excision repair, Gene, Chemotherapy, Single-nucleotide polymorphism, DNA repair, Biology, Cancer