The Influence on the Single Nucleotide Polymorphisms of ERCC1,ERCC2 to the Digestive System Cancers

DNA repair Organism such as nucleotide excision repair which have an important role in the maintenance of genome integrity,repairing damage caused by cancer-causing factors and the anticancer process.A number of nucleic acid repair genes such as excision repair cross-complementing gene 1(ERCC1) and human xeroderma pigmentosum gene D(XPD/ERCC2),the level descent may be susceptible factors to one or certain kinds of tumors;but if these genes′ level are higher,the ability to repair damage and chemotherapy-induced genetic damage will be enhanced,it may be resistance to chemotherapeutic drugs.The single nucleotide polymorphisms of the two genes have certain relationship with DDP,5-FU-based chemotherapy efficacy,and more application of gastrointestinal cancer use platinum agents and 5-FU treatment,so this paper will summarize the relationship of occurrence and effect between ERCC1,XPD / ERCC2 and several common gastrointestinal cancer.