2001•Unpublished venueRequires access

Effects of fluoride on lipid peroxidation and the capacity of an ti-oxidation of rats

梁刚, 孙贵范, 李影奕, 戴国钧

Abstract

Objective To study the effects of fluoride on contents of MDA and the activities of SOD and GSH-Px in organism.Methods By means of subchronic animal experiment.Results In the fluoride-treated group:The contents of MDA in serum,liver,kidney and brain of rat increased significantly.The activitie s of SOD in blood,liver,kidney,heart and testis decreased significantly.The acti vities of GSH-Px in blood decreased strikingly.Conclusions The results showed that fluoride could induce lipid peroxidation and decrease the capacity of antioxidaase(SOD,GSH-Px).

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Key concepts: Lipid peroxidation, Fluoride, Chemistry, Kidney, Glutathione, Biochemistry, Internal medicine, Endocrinology