Genotype of human papilloma virus among 1 074 male outpatients

Objective To understand the prevalence and genotype distribution of human papillomavirus among male patients attending to venereal outpatient department and provide basic data for prevention and treatment of HPV. Methods Retrospective analysis method was used to analyze 1 074 patients from venereal outpatient department of Beijing Friendship Hospital during January to August in 2015.Swab specimen were analyzed by flow-through hybridization and gene chip to detect the type of HPV.Chi-square test was used to compare the distribution of CA and suspected patients. Results Among the 434 CA samples, the positive rate was 72.6%(315/434). The 58.1%(252/434) samples were high risk HPV positive and 14.5%(63/434) samples were low risk HPV positive. In high risk HPV infection, multiple infection accounted for 40.4%(175/434) and single infection was 17.7%(77/434), while in low risk HPV infection, single infection accounted for 12.9%(56/434). HPV-11, HPV-6, HPV-16, HPV-52, HPV-58 and HPV-51 were common. The positive rate among suspected CA patients was 36.6%(234/640), and dominated in high risk HPV infection 25.3%(162/640). The positive rates of high risk HPV in CA patients[40.4%(175/434) and 17.7%(77/434)]were obviously higher than that of suspected ones[12.9%(56/434) and 1.6%(7/434)], χ2=95. 956 and 9.122, both P<0.05. Conclusions Male patients from venereal outpatient department have a high prevalence of HPV, and common genotype are HPV-11, HPV-6, HPV-16, HPV-52, HPV-58 and HPV-51. The intensity of HPV screening should be strengthened in order to provide the vital basis for the prevention and treatment HPV related diseases.(Chin J Lab Med, 2016, 39: 625-628) Key words: Papillomaviridae; Genotype; Papillomavirus infections; Condylomata acuminate