Effect of synchronized intermittent mandatory ventilation combined with pressure support on neonatal meconium aspiration syndrome and its nursing

Objective To discuss the clinical effect of synchronized intermittent mandatory ventilation （SIMV） combined with pressure support （PS） on neonatal meconium aspiration syndrome （NMAS） and its nursing. Methods Forty cases of NMAS children were divided into the control group and the observation group according to the ventilation mode, each with 20 cases. The control group received SIMV while the observation group received SIMV with PS. Oxygen time, duration of mechanical ventilation and length of stay were observed, and changes of mean arterial pressure （ MABP）, mean airway pressure （MAP） and oxygenation index （OI） were observed after treatment. Results Time of oxygen, mechanical ventilation and length of stay was significantly shorter than those in the control group [ （4.9 ± 1.1 ） d vs （ 5.6 ± 0.7 ） d, （65.7±7.0） h vs （75.1 ±9.2） h, （7.9 ±1.4） d vs （10. 1 ±2.0） d], and the differences were statistically significant （t = 2.401,3. 636,4. 030, respectively; P 〈 0. 05）. Before treatment, MABP in both groups was stable. After 36 hours of treatment, the MAP and OI was （7.4 ± 0.9） cmH20 and （4.7 ± 1.8 ） in the observation group, lower than （8.1 ± 1.1 ）cmH20 and（ 10. 1 ± 3.4）in the control group, and the differences were statistically significant （t = 2. 203,6. 698, respectively;P 〈 0. 05 ）. Conclusions SIMV combined with PS ventilation can improve children＇s oxygenation and reduce mean arterial pressure and airway pressure ventilation, which is conducive to the early offline and reduce ventilation time. Close attention to patients＇ status and airway nursing can improve the therapeutic effect. Key words: Infant, newly born;  Meconium aspiration syndrome;  Synchronized intermittent mandatory ventilation;  Pressure support