2017•Zhongguo xiaoer jijiu yixueRequires access
Clinical research progress on high mobility group protein box 1
Yufeng Zhang, Huiling Deng, Jia Fu, Xiaoyan Wang, Yu Zhang, Yan Xie, Juan Yuan, Pengfei Xu
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Abstract
High mobility group protein box 1 (HMGB1) is a highly conserved DNA binding protein, which is found in the nucleus of a variety of cells in the body, regulating the transcription of cell genes.It plays a role of nuclear binding protein in physiological state.Once released into the cell gap, it performances the role of inflammatory mediators.Recent studies showed that pathogenesis of HMGB1 not only involved in sepsis, autoimmune diseases, chronic liver disease, malignant tumor, but also involved in cell injury repair, which plays important role in a variety of diseases, organ damage, repair process.
Key words:
High mobility group protein box1; Physiological characteristics; Clinical disease,