Comparison of Letrozol regimen for ovulation induction in elderly or younger patients with polycystic ovary syndrome

Objective To compare the efficacy of Letrozol （ LE） regimen for ovulation induction in elderly and younger patients with polycystic ovary syndrome （PCOS）.Methods A total of 67 ovulation induction cycle by LE regimen in patients elderly than 35 years old or younger than 28 years old with PCOS were studied .The endometrial thickness,morphology,number of dominant follicles,ovulation on the day of injection HCG and pregnancy outcome were recorded.Results The endometrial thickness were significantly different between the two groups [（7.9 ±1.7） mm vs （9.4 ±3.2）mm,t=2.648,P〈0.05],but the endometrial morphology of AB type ,the number of dominant follicles and ovulation,pregnancy rate were indifferent [71.9% vs 77.8%,（1.5 ±1.5） vs （1.4 ±1.2）,（1.3 ± 0.8） vs （1.4 ±1.2）,37.5%vs 27.8%,t=2.456,1.995,1.758,1.525,all P〉0.05].Conclusion LE regimen for ovulation induction is effective for PCOS patients of all ages ,although the elderly patients with endometrial thick-ness is less than that in younger ones .The number of dominant follicles ,endometrial morphology and ovulation is no different,don′t reduce pregnancy rates . Key words: Polycystic Ovary Syndrome; Age; Letrozole