EFFICACY OF IMMEDIATE OVULATION INDUCTION FOR PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Objective To establish a new method of immediate ovulation induction(IOI) for sterile female with polycystic ovary syndrome(PCOS). Methods This study consisted of 100 infertile patients with PCOS,who were equally divided into study group and control group.The criteria of enrolment in study group were: ① immediate hormone detection,with normal androgen,and LH/FSH2;② immediate detection of endometrium,the thickness was 0.4-0.6 cm;③ immediate ultrasonographic detection of ovary,with less than 4.0 cm in diameter.The patients in this group received IMI therapy,and those in control group were enrolled from out-patient sterile female with PCOS,a conventional ovulation-induction was given to them on day 5 after menses(natural or after using progesterone).The follicular development,ovulation and pregnancy in the first cycle of ovulation were observed. Results The numbers of vesicula graafianae,thickness of endometrium,follicular diameter,ovulation and pregnancy rates in study group and control group were 2.8±0.4 vs 3.1±0.5,(1.12±0.31) vs(1.09±0.28) cm,(1.81±0.35) vs(1.92±0.36) cm,82.8% vs 84.3% and 26.0% vs 24.0%,respectively,the differences being not significant(P0.05),and the rates of OHSS and miscarriage were similar. Conclusion Immediate ovulation induction is safe and effective for the treatment of infertility caused by PCOS,the ovulation rate and pregnancy are similar to that of conventional technique.