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Experimental Study on Vascular Muscle Flap Combined With Bone Morphogenetic Protein for Forming Bone Bridge to Repair Bone Defect

Pei guo Xian, 杨润功, 魏宽海, J.M. Dan⁎

Abstract

目的探讨带血供肌瓣作为骨形态发生蛋白(BMP)载体修复骨缺损的可行性.方法观察带血供肌瓣复合BMP和单纯BMP组修复骨缺损时的成骨情况,对四种不同载体的成骨能力进行比较.结果以指深屈肌支为蒂制备的带血供肌瓣复合BMP修复骨缺损,效果优于单纯BMP组.带血供肌瓣联合纤维蛋白粘合剂复合BMP组修复骨缺损,效果优于其它载体.结论带血供肌瓣可作为BMP的良好载体,带血供肌瓣联合纤维蛋白粘合剂作BMP的载体效果更优.

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Key concepts: Bone morphogenetic protein 2, Bone morphogenetic protein, Bridge (graph theory), Anatomy, Medicine, Biology, In vitro, Biochemistry