2007肿瘤研究与临床Requires access

Multidrug resistance mechanisms and reversal agents in gastric carcinoma cells

郝淑兰, 刘丽坤, 李宜放

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Abstract

中国胃癌的发病例数占全球总数的1/3.化疗是治疗胃癌的有效手段,但由于肿瘤细胞多药耐药性(MDR)的产生,化疗疗效往往不佳.深入探讨胃癌MDR产生机制,寻找有效低毒的多药耐药逆转剂,对提高化疗的有效性,延长患者的生存期有着重要的意义.从转运蛋白有关的耐药机制、酶系统有关的耐药机制、细胞凋亡与耐药、细胞因子等四方面肿瘤细胞MDR产生的机制做一简要综述。

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中国胃癌的发病例数占全球总数的1/3.化疗是治疗胃癌的有效手段,但由于肿瘤细胞多药耐药性(MDR)的产生,化疗疗效往往不佳.深入探讨胃癌MDR产生机制,寻找有效低毒的多药耐药逆转剂,对提高化疗的有效性,延长患者的生存期有着重要的意义.从转运蛋白有关的耐药机制、酶系统有关的耐药机制、细胞凋亡与耐药、细胞因子等四方面肿瘤细胞MDR产生的机制做一简要综述。

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Available abstract

中国胃癌的发病例数占全球总数的1/3.化疗是治疗胃癌的有效手段,但由于肿瘤细胞多药耐药性(MDR)的产生,化疗疗效往往不佳.深入探讨胃癌MDR产生机制,寻找有效低毒的多药耐药逆转剂,对提高化疗的有效性,延长患者的生存期有着重要的意义.从转运蛋白有关的耐药机制、酶系统有关的耐药机制、细胞凋亡与耐药、细胞因子等四方面肿瘤细胞MDR产生的机制做一简要综述。

Key concepts: Multiple drug resistance, Gastric carcinoma, Medicine, Cancer, Carcinoma, Resistance (ecology), Drug resistance, Internal medicine

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Multidrug resistance mechanisms and reversal agents in gastric carcinoma cells — Research Paper | ScholarLens