2017•Chin J Colorec Dis (Electronic Edition)Requires access
Progress in study of microRNA in inflammatory bowel disease
Li-tian Wang, Lisheng Yang
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Abstract
Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease, mainly including ulcerative colitis (UC) and crohn′s disease (CD). The etiology of IBD has not yet been clarified, and it may be relevant to many factors. Recent studies have shown that expressions of microRNA (miRNA) were frequently altered in patients with IBD, and were involved in the development of IBD. This article reviewed the aberrant miRNA expressions in patients with IBD in order to discuss the value of miRNA in the pathogenesis, diagnosis and prognosis of IBD, and to further provide the evidence for its clinical application.
Key words:
Digestive system; Colitis, ulcerative; Crohn disease; microRNA