The study on the change of carotid atherosclerotic plaque and blood vessels active matter in patients with cerebral infarction

Objective To study the relationship between carotid atherosclerotic plaque and levels of plasma IL-18,CRP,adiponectin(APN)in cerebral infarction patients with diabetes mellitus(DM).Methods Fouty cases of cerebral infarction patients with DM(A group)and 40 case without DM(B group)were randomly selected.All patients with CI were examined on carotid arteries using color Doppler Ultrasonography.Levels of plasma IL-18,CRP and APN were examined and analyzed.Results There were 36 patients(90％)with atberosclerotic plaque and 4 patients(10％)without in group A,among them,28 cases(70％)with vulnerable plaque and 8 cases(20％)with non-vulnerable plaque.There were 26 patients(65％)with atherosclerotic plaque and 14 patients(35％)without in group B,among them,16 cases(61.4％)with vulnerable plaque and 10 cases (38.6％)with non-vulnerable plaque.The level of plasma adiponectin([5.22 ± 1.79]mg/L)in group A was significantly lower than that([7.24 ± 2.31]mg/L)in group B,and there was significant difference between these two groups(t =2.42,P ＜ 0.05).The levels of IL-18([213.5 ± 25.24]μg/L)and CRP([5.42 ± 2.14]mg/L)in group A were obviously higher than those([187.86 ± 23.13]μg/L and[3.57 ± 1.12]mg/L)in group B,and there was significant difference between these two groups(t =5.72,3.551 resectively,P ＜ 0.05)Conclusions Adipenectin might be a protective factor in the development of atherosclemsis in diabetes mellitus.The elevation level of IL-18 and CRP may related with instability of plaque and the occurrence of cerebral infarction. Key words: Diabetes mellitus;  Interleukin-18 ;  C-reactive protein;  Adipinectin;  Carotid Atherosclerotic Plaque