ScholarLens Back to search
2011•Central Plains Medical JournalRequires access

Effect of curcumin on proliferative inhibition of human esophageal cancer cell line EC-9706

Mingjie Li, Gaofeng Lu, Tang Fuai

Open publisher page 0 citations

Abstract

Objective To explore the effect of curcumin on the proliferative inhibition of human esophageal cancer cell line EC-9706 and study the molecular mechanism. Methods After EC-9706 cells were treated with 50-200 μmol/L curcumin for 12-48 h,Methyl thiazolyl tetrazolium (MTT) method was used to detect the inhibition rates, and the expression of HSP70 mRNA was analyzed by RT-PCR. Results After curcumin treatment, the growth of EC-9706 cells was inhibited significantly in a time and dose-dependent manner, and the inhibition rates were 18.3%-77.5%(P<0.05).The expression of HSP70 mRNA was down-regulated (P<0.05). Conclusions Curcumin could effectively inhibit the proliferation of EC-9706 cells.Its mechanism may be inhibition of HSP70 mRNA expression. Key words: Curcumin;  Esophageal cancer;  HSP70

About this research paper

What this paper is about

Objective To explore the effect of curcumin on the proliferative inhibition of human esophageal cancer cell line EC-9706 and study the molecular mechanism. Methods After EC-9706 cells were treated with 50-200 μmol/L curcumin for 12-48 h,Methyl thiazolyl tetrazolium (MTT) method was used to detect the inhibition rates, and the expression of HSP70 mRNA was analyzed by RT-PCR. Results After curcumin treatment, the growth of EC-9706 cells was inhibited significantly in a time and dose-dependent manner, and the inhibition rates were 18.3%-77.5%(P<0.05).The expression of HSP70 mRNA was down-regulated (P<0.05). Conclusions Curcumin could effectively inhibit the proliferation of EC-9706 cells.Its mechanism may be inhibition of HSP70 mRNA expression. Key words: Curcumin;  Esophageal cancer;  HSP70

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the effect of curcumin on the proliferative inhibition of human esophageal cancer cell line EC-9706 and study the molecular mechanism. Methods After EC-9706 cells were treated with 50-200 μmol/L curcumin for 12-48 h,Methyl thiazolyl tetrazolium (MTT) method was used to detect the inhibition rates, and the expression of HSP70 mRNA was analyzed by RT-PCR. Results After curcumin treatment, the growth of EC-9706 cells was inhibited significantly in a time and dose-dependent manner, and the inhibition rates were 18.3%-77.5%(P<0.05).The expression of HSP70 mRNA was down-regulated (P<0.05). Conclusions Curcumin could effectively inhibit the proliferation of EC-9706 cells.Its mechanism may be inhibition of HSP70 mRNA expression. Key words: Curcumin;  Esophageal cancer;  HSP70

Key concepts: Curcumin, Cell culture, Molecular biology, Chemistry, Hsp70, Messenger RNA, Cell growth, Cancer research

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of curcumin on proliferative inhibition of human esophageal cancer cell line EC-9706 — Research Paper | ScholarLens